Animal models have long shaped how biomedical research is conducted. They have influenced how diseases are studied, how risks are assessed, and how potential treatments move from early discovery ...

Every year, millions of animals are used in laboratories, and for many people, the image is immediate and uncomfortable: ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

New grants support organoids, organs-on-chips, and in silico approaches to reduce reliance on animal models, but experts say ...

Carlin is a vice president at Pathway Policy Group and a veterinarian. Paragas is the CEO and founder of DVLP Medicines and a virologist. The Food and Drug Administration’s recent decision to phase ...

Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

For decades, the pharmaceutical industry has discussed moving away from in vivo models in preclinical research. Now, it’s more than a conversation. The FDA’s roadmap for reducing animal testing, ...

The recent creation of the NIH Office of Research Integrity, Validation, and Adoption of New Approach Methodologies (ORIVA) is more than just an administrative shift. It represents a historic ...